For general questions please contact our Customer Service:
Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Phone: +49 6151 72-0
Fax: +49 6151 72 2000
06 February 2012
loading
Inhibits trypsin-like serine proteinases. Irreversibly inactivates trypsin without affecting chymotrypsin. Prevents nitric oxide production by activated macrophages by interfering with transcription of the iNOS gene. Blocks cell-cell adhesion and binding of HIV-1 virus to the target cells. In macrophages, blocks nitric oxide synthase induced by interferon-γ and lipopolysaccharides (EC50 = 80 µM). Prevents endonucleolysis accompanying apoptotic death of HL-60 leukemia cells and normal thymocytes.
| Product information | |||
|---|---|---|---|
| Form | Off-white solid | ||
| Primary Target | trypsin like proteases | ||
| Secondary target | blocks NOS induced by interfuron-g | ||
| Molar mass | 369.3 | ||
| Hygrocopic | Yes | ||
| Purity | ≥95% by elemental analysis | ||
| Solubility | aqueous solutions (unstable above pH 6.0) | ||
| Chemical formula | C14H21ClN2O3S . HCl | ||
| RTECS | XT5160000 | ||
| CAS number | 4238-41-9 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Irritant |
||
| Safety information | |||
|---|---|---|---|
| S Phrase |
S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing. |
||
| R Phrase |
R: 36/37/38 Irritating to eyes, respiratory system and skin. |
||
