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06 February 2012
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A thiol containing amido-acid that selectively binds to the active site zinc of metalloproteinases and blocks their activity (IC50 = 2.1 nM for neutral endopeptidase-NEP). Although it is shown to inhibit the activity for Aβ peptide degrading enzyme neprilysin in vitro, it has no effect on the secretion of Aβ peptide or amyloid β precursor protein (APP). Also reported to inhibit the activity of angiotensin-converting enzyme (ACE) at much higher concentrations (IC50 = 14 µM); however, it does not affect the activity of endothelin-converting enzyme.
| Product information | |||
|---|---|---|---|
| Form | White solid | ||
| Primary Target | NEP activity | ||
| Primary Target IC50 | 2.1 nM | ||
| Secondary target | ACE (IC50 = 14 mM) | ||
| Molar mass | 253.3 | ||
| Protect from Light | Yes | ||
| Protect from Moisture | Yes | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥95% by TLC | ||
| Solubility | DMSO or EtOH | ||
| Chemical formula | C12H15NO3S | ||
| CAS number | 76721-89-6 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
||
